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Article

The effect of childhood trauma on serum BDNF in bipolar depression is modulated by the serotonin promoter genotype.

Neuroscience letters - 24 Aug 2017

Benedetti Francesco, Ambrée Oliver, Locatelli Clara, Lorenzi Cristina, Poletti Sara, Colombo Cristina, Arolt Volker

Abstract excerpt

In healthy humans, both childhood trauma and the short form of the serotonin promoter transporter genotype (5-HTTLPR) are associated with lower levels of brain-derived neurotrophic factor (BDNF). In subjects with bipolar disorder (BD), lower levels of BDNF and a higher degree of childhood trauma were observed compared with healthy controls. However, is still unknown if the functional 5-HTTLPR polymorphisms exerts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28754344
DOI: 10.1016/j.neulet.2017.07.043

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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