Article
Mitochondrial DNA polymorphisms, its copy number change and outcome in colorectal cancer.
BMC research notes - 27 Jun 2015
Mohideen Asan Meera Sahib Haja, Dicks Elizabeth, Parfrey Patrick, Green Roger, Savas Sevtap
Abstract excerpt
BACKGROUND: Mitochondrion is a small organelle inside the eukaryotic cells. It has its own genome (mtDNA) and encodes for proteins that are critical for energy production and cellular metabolism. Mitochondrial dysfunctions have been implicated in cancer progression and may be related to poor prognosis in cancer patients. In this study we hypothesized that genetic variations in mtDNA are associated with clinical...
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