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Article

Is cumulative frequency of mitochondrial DNA variants a biomarker for colorectal tumor progression?

Molecular cancer - 13 Oct 2004

Aikhionbare Felix O, Khan Masood, Carey Delicia, Okoli Joel, Go Rodney

Abstract excerpt

To examine the relationship between mitochondrial DNA (mtDNA) alterations and colorectal tumorigenesis, we used high-resolution restriction endonucleases and sequencing to assess the mitochondrial genome from three histologic subtypes of colorectal adenomas (tubular = 8; tubulovillous = 9; and villous = 8), colorectal cancer (CRC) tissues = 27, and their matched surrounding normal tissue (MSNT) = 52. The...

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Identifiers

PMID: 15482594
DOI: 10.1186/1476-4598-3-30
PMCID: PMC526214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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