Article
Clinical value of mitochondrial mutations in colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 May 2005
Lièvre Astrid, Chapusot Caroline, Bouvier Anne-Marie, Zinzindohoué Franck, Piard Françoise, Roignot Patrick, Arnould Laurent, Beaune Philippe, Faivre Jean, Laurent-Puig Pierre
Abstract excerpt
PURPOSE: Prognostic factors that could select high-risk recurrence colorectal cancer patients and predict chemosensitivity are needed. Since mutations of mitochondrial DNA (mtDNA) have been described in different types of cancers and since they may play a role in response to anticancer agents, we investigated in a population-based series of colorectal cancer patients the clinical value of mtDNA mutations....
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