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Article

Mutational signature of mtDNA confers mechanistic insight into oxidative metabolism remodeling in colorectal cancer.

Theranostics - 1 Jan 2023

Guo Wenjie, Liu Yang, Ji Xiaoying, Guo Shanshan, Xie Fanfan, Chen Yanxing, Zhou Kaixiang, Zhang Huanqin, Peng Fan, Wu Dan, Wang Zhenni, Guo Xu, Zhao Qi, Gu Xiwen, Xing Jinliang

Abstract excerpt

Rationale: Mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) mutations and subsequent metabolic defects are closely involved in tumorigenesis and progression in a cancer-type specific manner. To date, the mutational pattern of mtDNA somatic mutations in colorectal cancer (CRC) tissues and its clinical implication are still not completely clear. Methods: In the present study, we generated a large mtDNA...

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Identifiers

PMID: 36593960
DOI: 10.7150/thno.78718
PMCID: PMC9800724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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