Article

Degree and site of chromosomal instability define its oncogenic potential

2019-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor formation have not unequivocally emerged from animal studies and are thus still unclear. CIN can both promote and suppress tumorigenesis, but variances in mechanisms and timings of CIN induction in different oncogenic backgrounds...

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Literature Corpus work: 25fd1bc1-91e1-5605-b6f1-a6e0ff7f5781
DOI: 10.1101/638460

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