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Article

Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestine

27 Apr 2019

Abstract excerpt

Mismatch repair (MMR)-deficiency increases the risk of colorectal tumorigenesis. To determine whether the tumors develop on a normal or disturbed epigenetic background and how radiation affects this, we quantified genome-wide histone H3 methylation profiles in macroscopic normal intestinal tissue of young radiated and untreated MMR-deficient VCMsh2 LoxP/LoxP ( Msh2 −/− ) mice months before tumor onset. Histone H3...

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PMID: 31029155
DOI: 10.1186/s13148-019-0639-8

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