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Loss of heterozygosity in spontaneous and x-ray-induced intestinal tumors arising in F1 hybridMin mice: Evidence for sequential loss ofApc+ andDpc4 in tumor development

1 Jan 2000

Abstract excerpt

Min (multiple intestinal neoplasia) mice carry a mutant allele of the murine Apc (adenomatous polyposis coli) locus and are predisposed to intestinal adenoma formation in the intestinal tract. Early studies have shown complete loss of function of Apc by whole chromosome loss on the tumor-sensitive C57BL/6J genetic background and in AKR x B6 F1 hybrids. Gamma-radiation-induced chromosomal losses focus the critical...

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PMID: 10862047
DOI: 10.1002/1098-2264(200008)28:4<387::aid-gcc4>3.0.co;2-h

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Loss of heterozygosity in spontaneous and x-ray-induced intestinal tumors arising in F1 hybridMin mice: Evidence for sequential loss ofApc+ andDpc4 in tumor developmentPMID 10862047Read ↗

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