Article
CYP2C19 genotypes in a population of healthy volunteers and in children with hematological malignancies in Gaza Strip.
The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique - 1 Jan 2009
Sameer Abu-Eid I, Amany Gharbieh M, Abdela Abed A, Fadel Sharif A
Abstract excerpt
BACKGROUND: Cytochrome P450 2C19 (CYP2C19) participates in the metabolism of many clinically important drugs and xenobiotic compounds. Genetic polymorphisms of the CYP2C19 gene are described to have possible effect on drug treatment and increasing susceptibility to carcinogenic substances. The aim of this study was to determine the frequencies of the common polymorphic CYP2C19 alleles (CYP2C19*2 and CYP2C19*3) in...
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