Article
CYP2C19 polymorphisms in patients with gastric and colorectal carcinoma.
International journal of gastrointestinal cancer - 1 Jan 2006
Tamer L, Ercan B, Ercan S, Ateş N, Ateş C, Ocal K, Dirlik M, Aydin S, Atik U
Abstract excerpt
BACKGROUND: It has been reported that up to 80% of human cancers arise as a consequence of environmental exposure and host susceptibility factors. Environmental carcinogens are predominantly metabolized by the cytochrome P450 (CYP) superfamily of drug- or xenobiotic-metabolizing enzymes. Genetic variations in these enzymes affect individuals' susceptibility to carcinogens. AIM OF THE STUDY: The aim of this study...
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