Article
Prevalence of five pharmacologically most important CYP2C9 and CYP2C19 allelic variants in the population from the Republic of Srpska in Bosnia and Herzegovina.
Arhiv za higijenu rada i toksikologiju - 28 Jun 2021
Vidović Stojko, Škrbić Ranko, Stojiljković Miloš P, Vidović Vanja, Bećarević Jelena, Stoisavljević-Šatara Svjetlana, Maksimović Nela
Abstract excerpt
The enzymes of the cytochrome P450 superfamily play a critical role in phase I drug metabolism. Among them, CYP2C9 and CYP2C19 are clinically important, as they can mediate severe toxicity, therapy failure, and increased susceptibility to cancer and other diseases caused by chemicals. The aim of this study was to determine the prevalence of pharmacologically most important allelic variants of the CYP2C9 and...
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