Article
High prevalence of CYP2C19*2 allele in Roma samples: study on Roma and Hungarian population samples with review of the literature.
Molecular biology reports - 1 Aug 2013
Sipeky Csilla, Weber Agnes, Szabo Melinda, Melegh Bela I, Janicsek Ingrid, Tarlos Greta, Szabo Istvan, Sumegi Katalin, Melegh Bela
Abstract excerpt
The purpose of our study was to characterise the CYP2C19*2 and CYP2C19*3 alleles in healthy Roma and Hungarian populations. DNA of 500 Roma and 370 Hungarian subjects were genotyped for CYP2C19*2 (G681A, rs4244285) and CYP2C19*3 (G636A, rs4986893) by PCR-RFLP assay and direct sequencing. Significant differences were found comparing the Roma and Hungarian populations in CYP2C19 681 GG (63.6 vs. 75.9%), GA (31.8...
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