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Estimation of polymorphisms in the drug-metabolizing enzyme, cytochrome P450 2C19 gene in six major ethnicities of Pakistan.

Bioengineered - 1 Dec 2021

Ahmed Sagheer, Gul Saima, Akhlaq Muhammad, Hussain Abrar, Tariq Khan Sidrah, Rehman Halimur, Hanif Bangash Muhammad, Al Mughairbi Fadwa, Hamid Hamdard Muhammad

Abstract excerpt

Interindividual differences in cytochrome P450 (CYP) 2C19 activity may result in variations in the therapeutic response to drugs metabolized by this enzyme. Differences at gene level may translate into protein level with consequent impairment of the enzyme activity. As a result patients with such genetic differences might experience undesirable effects or no effect at all. The aim of the present study was to find...

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Identifiers

PMID: 34308762
DOI: 10.1080/21655979.2021.1955809
PMCID: PMC8806689

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