Article
Identification of sequence variants in the UBL5 (ubiquitin-like 5 or BEACON) gene in obese children by PCR-SSCP: no evidence for association with obesity.
Journal of pediatric endocrinology & metabolism : JPEM - 1 Dec 2008
Sentinelli Federica, Romeo Stefano, Cambuli Valentina M, Cossu Efisio, Cavallo Maria Gisella, Zavarella Sara, Spoletini Marialuisa, Buzzetti Raffaella, Baroni Marco Giorgio
Abstract excerpt
BACKGROUND: Childhood obesity has a strong genetic background. The human UBL5 (BEACON) gene has been suggested as a candidate gene for obesity. Previous studies in populations of different ethnicities have shown a significant association between UBL5 variants and measures of body fatness. AIMS: To identify mutations that may cause early-onset obesity we screened the UBL5 gene for sequence variations in a cohort...
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