Article
A polymorphism in the 5' untranslated region of the human ob gene is associated with low leptin levels.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Mar 1998
Hager J, Clement K, Francke S, Dina C, Raison J, Lahlou N, Rich N, Pelloux V, Basdevant A, Guy-Grand B, North M, Froguel P
Abstract excerpt
OBJECTIVE: To search the human ob gene for mutations and evaluate their role in massive obesity. DESIGN: Direct mutation screening of the gene and case-control association study. Multivariate analyses for evaluation of differences in clinical parameters. SUBJECTS: Primary mutation screening: 24 morbidly obese subjects (body mass index (BMI) > 40 kg/m2). Association study: 395 unrelated morbidly obese subjects...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.