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Article

Analysis of the uncoupling protein-1 (UCP1) gene in obese and lean subjects: identification of four amino acid variants.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Sept 1998

Hamann A, Tafel J, Büsing B, Münzberg H, Hinney A, Mayer H, Siegfried W, Ricquier D, Greten H, Hebebrand J, Matthaei S

Abstract excerpt

Uncoupling protein-1 (UCP1) is uniquely expressed in brown adipose tissue (BAT) and of major importance for the tissues thermogenic capacity. This study was undertaken to detect variants in the UCP1 gene by single strand conformational polymorphism (SSCP) analysis and subsequent sequencing, and determine their potential association with obesity. Four variants predicting for amino acid substitutions were detected,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9756256
DOI: 10.1038/sj.ijo.0800725

Genes

UCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Analysis of the uncoupling protein-1 (UCP1) gene in obese and lean subjects: identification of four amino acid variants.PMID 9756256Read ↗

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The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus.Semantic proximity Read ↗

DNA polymorphism in the uncoupling protein 1 (UCP1) gene has no effect on obesity related phenotypes in the Swedish Obese Subjects cohorts.Semantic proximity Read ↗

Frequency and significance of the A-->G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort.Semantic proximity Read ↗

The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research.Semantic proximity Read ↗

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and Type II diabetes.Semantic proximity Read ↗

UCP1, the mitochondrial uncoupling protein of brown adipocyte: A personal contribution and a historical perspective.Semantic proximity Read ↗

Role of the Polymorphisms of Uncoupling Protein Genes in Childhood Obesity and Their Association with Obesity-Related Disturbances.Semantic proximity Read ↗

The UCP1 gene polymorphism A-3826G in relation to DM2 and body composition in Czech population.Semantic proximity Read ↗

Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity.Semantic proximity Read ↗

Uncoupling protein 1 gene -3826 A/G polymorphism is associated with weight loss on a short-term, controlled-energy diet in young women.Semantic proximity Read ↗

Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control studySemantic proximity Read ↗

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