Article
Association of genetic variation within UBL5 with phenotypes of metabolic syndrome.
Human biology - 1 Apr 2006
Bozaoglu Kiymet, Curran Joanne E, Elliott Kate S, Walder Ken R, Dyer Thomas D, Rainwater David L, VandeBerg John L, Comuzzie Anthony G, Collier Greg R, Zimmet Paul, MacCluer Jean W, Jowett Jeremy B, Blangero John
Abstract excerpt
The BEACON gene was initially identified using the differential display polymerase chain reaction on hypothalamic mRNA samples collected from lean and obese Psammomys obesus, a polygenic animal model of obesity. Hypothalamic BEACON gene expression was positively correlated with percentage of body fat, and intracerebroventricular infusion of the Beacon protein resulted in a dose-dependent increase in food intake...
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