Article
Genetic variation in BEACON influences quantitative variation in metabolic syndrome-related phenotypes.
Diabetes - 1 Sept 2004
Jowett Jeremy B, Elliott Kate S, Curran Joanne E, Hunt Nicola, Walder Ken R, Collier Greg R, Zimmet Paul Z, Blangero John
Abstract excerpt
The BEACON gene (also known as UBL5) was identified as differentially expressed between lean and obese Psammomys obesus, a polygenic animal model of obesity, type 2 diabetes, and dyslipidemia. The human homologue of BEACON is located on chromosome 19p, a region likely to contain genes affecting metabolic syndrome-related quantitative traits as established by linkage studies. To assess whether the human BEACON...
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