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Article

Identification of a loss-of-function mutation in Ube2l6 associated with obesity resistance.

Diabetes - 1 Aug 2013

Marcelin Genevieve, Liu Shun-Mei, Schwartz Gary J, Chua Streamson C

Abstract excerpt

We previously mapped a locus on BALB/c chromosome 2 associated with protection from leptin-deficiency-induced obesity. Here, we generated the corresponding congenic mouse strain by introgression of a segment of C57BL/6J chromosome 2 to the BALB/c background to confirm the genotype-phenotype associations. We found that the BALB/c alleles decreased fat mass expansion by limiting adipocyte hyperplasia and adipocyte...

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Share to 3T3-L1 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23557705
DOI: 10.2337/db12-1054
PMCID: PMC3717837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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