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Article

Absence of mutations in the human OB gene in obese/diabetic subjects.

Diabetes - 1 May 1996

Maffei M, Stoffel M, Barone M, Moon B, Dammerman M, Ravussin E, Bogardus C, Ludwig D S, Flier J S, Talley M

Abstract excerpt

The product of the obese (ob) gene, leptin, is a secreted protein that is important in the regulation of body weight. Mice with mutations in the ob gene are obese and diabetic and manifest reduced physical as well as metabolic activity. In this study, we tested the possibility that mutations in the OB gene may contribute to human obesity. We report the isolation and partial sequence of the human OB gene and the...

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Identifiers

PMID: 8621022
DOI: 10.2337/diab.45.5.679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of mutations in the human OB gene in obese/diabetic subjects.PMID 8621022Read ↗

Mutation screening and identification of a sequence variation in the human ob gene coding region.Semantic proximity Read ↗

Identification of two novel missense mutations in the human OB gene.Semantic proximity Read ↗

A polymorphism in the 5' untranslated region of the human ob gene is associated with low leptin levels.Semantic proximity Read ↗

Obese (ob) gene defects are rare in human obesity.Semantic proximity Read ↗

Markers for the gene ob and serum leptin levels in human morbid obesity.Semantic proximity Read ↗

Molecular screening of both the promoter and the protein coding regions in the human ob gene in Japanese obese subjects with non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

OB gene not linked to human obesity in Mexican American affected sib pairs from Starr County, Texas.Semantic proximity Read ↗

Human leptin receptor gene in obese Japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity.Semantic proximity Read ↗

A novel microsatellite polymorphism in the human OB gene: a highly polymorphic marker for linkage analysis.Semantic proximity Read ↗

A rapid PCR-based method for the identification of ob mutant mice.Semantic proximity Read ↗

Genetic variants of the human obesity (OB) gene in subjects with and without Prader-Willi syndrome: comparison with body mass index and weight.Semantic proximity Read ↗

Structural Organization and Chromosomal Assignment of the Human obese GeneSemantic proximity Read ↗

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