Article
Absence of mutations in the human OB gene in obese/diabetic subjects.
Diabetes - 1 May 1996
Maffei M, Stoffel M, Barone M, Moon B, Dammerman M, Ravussin E, Bogardus C, Ludwig D S, Flier J S, Talley M
Abstract excerpt
The product of the obese (ob) gene, leptin, is a secreted protein that is important in the regulation of body weight. Mice with mutations in the ob gene are obese and diabetic and manifest reduced physical as well as metabolic activity. In this study, we tested the possibility that mutations in t...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Diabetes Mellitus
- Genomic Library
- Humans
- Leptin
- Male
- Mice
- Molecular Sequence Data
- Mutation
- Obesity
- Oligodeoxyribonucleotides
- Polymorphism, Genetic
- Proteins
- Repetitive Sequences, Nucleic Acid