Article
AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin.
Circulation - 17 Feb 2009
Wang Yajing, Gao Erhe, Tao Ling, Lau Wayne Bond, Yuan Yuexin, Goldstein Barry J, Lopez Bernard L, Christopher Theodore A, Tian Rong, Koch Walter, Ma Xin-Liang
Abstract excerpt
BACKGROUND: Diabetes increases the morbidity/mortality of ischemic heart disease, but the underlying mechanisms are incompletely understood. Deficiency of both AMP-activated protein kinase (AMPK) and adiponectin occurs in diabetes, but whether AMPK is cardioprotective or a central mediator of adiponectin cardioprotection in vivo remains unknown. METHODS AND RESULTS: Male adult mice with cardiomyocyte-specific...
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