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Article

AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.

Circulation research - 15 Aug 2014

Zordoky Beshay N M, Nagendran Jeevan, Pulinilkunnil Thomas, Kienesberger Petra C, Masson Grant, Waller Terri J, Kemp Bruce E, Steinberg Gregory R, Dyck Jason R B

Abstract excerpt

RATIONALE: The energy sensor AMP-activated protein kinases (AMPK) is thought to play an important role in regulating myocardial fatty acid oxidation (FAO) via its phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC). However, studies supporting this have not directly assessed whether the maintenance of FAO rates and subsequent cardiac function requires AMPK-dependent inhibitory phosphorylation...

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Identifiers

PMID: 25001074
DOI: 10.1161/CIRCRESAHA.115.304538

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