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Article

Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2006

Zarrinpashneh Elham, Carjaval Karla, Beauloye Christophe, Ginion Audrey, Mateo Philippe, Pouleur Anne-Catherine, Horman Sandrine, Vaulont Sophie, Hoerter Jacqueline, Viollet Benoit, Hue Louis, Vanoverschelde Jean-Louis, Bertrand Luc

Abstract excerpt

AMP-activated protein kinase (AMPK) is a major sensor and regulator of the energetic state of the cell. Little is known about the specific role of AMPKalpha(2), the major AMPK isoform in the heart, in response to global ischemia. We used AMPKalpha(2)-knockout (AMPKalpha(2)(-/-)) mice to evaluate the consequences of AMPKalpha(2) deletion during normoxia and ischemia, with glucose as the sole substrate. Hemodynamic...

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Identifiers

PMID: 16877552
DOI: 10.1152/ajpheart.01032.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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