Augmentation of Histone Deacetylase 6 Activity Impairs Mitochondrial Respiratory Complex I in Ischemic/Reperfused Diabetic Hearts

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Diabetes augments activity of histone deacetylase 6 (HDAC6) and generation of tumor necrosis factor α (TNFα) and impairs the physiological function of mitochondrial complex I (mCI) which oxidizes reduced nicotinamide adenine dinucleotide (NADH) to nicotinamide adenine dinucleotide to sustain the tricarboxylic acid cycle and β-oxidation. Here we examined how HDAC6 regulates T...

Topics

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• Adenosine and Purinergic Signaling
• Autophagy in Disease and Therapy
• Cardiovascular Function and Risk Factors
• Diet and metabolism studies
• Histone Deacetylase Inhibitors Research
• Parkinson's Disease Mechanisms and Treatments
• Signaling Pathways in Disease
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

d3b5f146-9f79-550d-b0a6-cdfe4fc18be2

DOI

10.1101/2023.02.21.529462