Transient AMPK activation by nutrient stress of high fat diet preserves cardiac electrophysiological stability and protects against arrhythmias

Abstract excerpt

<h4>ABSTRACT</h4> Sudden cardiac death (SCD) is a major complication of obesity, yet it remains unclear whether early metabolic stress, prior to the onset of overt obesity or structural remodeling, can independently promote arrhythmias. In vitro studies suggest that fatty acids can allosterically stimulate AMP-activated protein kinase (AMPK), a key metabolic sensor known to preserve myocardial viability and mitoc...

Topics

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• AMP-Activated Protein Kinases
• Bradycardia
• Electrocardiography, Ambulatory
• Magnetic Resonance Imaging, Cine
• Physical Conditioning, Animal
• Physical Endurance
• Ryanodine Receptor Calcium Release Channel
• Sarcolemma

Identifiers and source

Literature Corpus work

ad91f5a6-5a65-5700-9eee-dfe230fedc9d

DOI

10.1101/2025.06.11.658631