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Article

Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.

FEBS letters - 9 Jan 2008

Hardie D Grahame

Abstract excerpt

Obesity, type 2 diabetes and the metabolic syndrome are disorders of energy balance, which the AMP-activated protein kinase (AMPK) regulates both at the cellular and whole body levels. AMPK switches cells from an anabolic state where nutrients are taken up and stored, to a catabolic state where they are oxidized. Drugs that activate AMPK indirectly (metformin and thiazolidinediones) are now the mainstay of...

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Identifiers

PMID: 18022388
DOI: 10.1016/j.febslet.2007.11.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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