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Article

Impaired macrophage migration inhibitory factor-AMP-activated protein kinase activation and ischemic recovery in the senescent heart.

Circulation - 20 Jul 2010

Ma Heng, Wang Jingying, Thomas D Paul, Tong Chao, Leng Lin, Wang Wenkui, Merk Melanie, Zierow Swen, Bernhagen Jürgen, Ren Jun, Bucala Richard, Li Ji

Abstract excerpt

BACKGROUND: Elderly patients are more sensitive than younger patients to myocardial ischemia, which results in higher mortality. We investigated how aging affects the cardioprotective AMP-activated protein kinase (AMPK) signaling pathway. METHODS AND RESULTS: Ischemic AMPK activation was impaired in aged compared with young murine hearts. The expression and secretion of the AMPK upstream regulator, macrophage...

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Identifiers

PMID: 20606117
DOI: 10.1161/CIRCULATIONAHA.110.953208
PMCID: PMC2907453

Genes

MIF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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