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Article

Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cells.

American journal of physiology. Renal physiology - 1 Apr 2009

Cook Natasha, Fraser Scott A, Katerelos Marina, Katsis Frosa, Gleich Kurt, Mount Peter F, Steinberg Gregory R, Levidiotis Vicki, Kemp Bruce E, Power David A

Abstract excerpt

The energy-sensing kinase AMP-activated protein kinase (AMPK) is associated with the sodium-potassium-chloride cotransporter NKCC2 in the kidney and phosphorylates it on a regulatory site in vitro. To identify a potential role for AMPK in salt sensing at the macula densa, we have used the murine macula densa cell line MMDD1. In this cell line, AMPK was rapidly activated by isosmolar low-salt conditions. In...

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Identifiers

PMID: 19176702
DOI: 10.1152/ajprenal.90372.2008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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