Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis.

Kidney international - 1 Jan 2018

Wang Yuguo, Jia Li, Hu Zhaoyong, Entman Mark L, Mitch William E, Wang Yanlin

Abstract excerpt

Chronic kidney disease is a major cause of death, and renal fibrosis is a common pathway leading to the progression of this disease. Although activated fibroblasts are responsible for the production of the extracellular matrix and the development of renal fibrosis, the molecular mechanisms underlying fibroblast activation are not fully defined. Here we examined the functional role of AMP-activated protein kinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix

Share to Fibrosis

Share to Myofibroblasts

Share to Renal Insufficiency, Chronic

Share to Reperfusion Injury

Share to Ureteral Obstruction

Source

Open in PubMed Open full text

Identifiers

PMID: 28739141
DOI: 10.1016/j.kint.2017.04.033
PMCID: PMC5750062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis.PMID 28739141Read ↗

AMP-activated protein kinase alleviates extracellular matrix accumulation in high glucose-induced renal fibroblasts through mTOR signaling pathway.Semantic proximity Read ↗

Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype.Semantic proximity Read ↗

The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transitionSemantic proximity Read ↗

TGF-β1/p53 signaling in renal fibrogenesis.Semantic proximity Read ↗

AMPK phosphorylation of the β1Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells.Semantic proximity Read ↗

AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation.Semantic proximity Read ↗

Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosisSemantic proximity Read ↗

Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis.Semantic proximity Read ↗

Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.Semantic proximity Read ↗

β-catenin-regulated Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosisSemantic proximity Read ↗

Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosisSemantic proximity Read ↗

MRTF: Basic Biology and Role in Kidney DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.