Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AMPK phosphorylation of the β1Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells.

American journal of physiology. Renal physiology - 1 Dec 2019

Ho Pei-Yin, Li Hui, Cheng Lei, Bhalla Vivek, Fenton Robert A, Hallows Kenneth R

Abstract excerpt

The metabolic sensor AMP-activated protein kinase (AMPK) inhibits the epithelial Na+ channel (ENaC), a key regulator of salt reabsorption by the kidney and thus total body volume and blood pressure. Recent studies have suggested that AMPK promotes the association of p21-activated kinase-interacting exchange factor-β1 β1Pix, 14-3-3 proteins, and the ubiquitin ligase neural precursor cell expressed developmentally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Epithelial Sodium Channels

Share to Gene Expression Regulation, Enzymologic

Share to Kidney Tubules, Collecting

Share to Nedd4 Ubiquitin Protein Ligases

Share to Rho Guanine Nucleotide Exchange Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 31566435
DOI: 10.1152/ajprenal.00592.2018
PMCID: PMC6962512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AMPK phosphorylation of the β1Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells.PMID 31566435Read ↗

AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated.Semantic proximity Read ↗

Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase.Semantic proximity Read ↗

AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis.Semantic proximity Read ↗

Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype.Semantic proximity Read ↗

Novel torin1-sensitive phosphorylation sites on the metabolic regulator AMPK revealed by label-free mass spectrometrySemantic proximity Read ↗

Interacting proteins of AMPK studied using TurboID proximity labeling technologySemantic proximity Read ↗

Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue.Semantic proximity Read ↗

Folliculin regulates ampk-dependent autophagy and metabolic stress survival.Semantic proximity Read ↗

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.Semantic proximity Read ↗

M1-linked Ubiquitination by LUBAC Regulates AMPK Activity and the Response to Energetic StressSemantic proximity Read ↗

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.Semantic proximity Read ↗

MiR‐184 expression is regulated by AMPK in pancreatic isletsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.