Article
Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase.
Biochemical and biophysical research communications - 20 May 2011
Alesutan Ioana, Munoz Carlos, Sopjani Mentor, Dërmaku-Sopjani Miribane, Michael Diana, Fraser Scott, Kemp Bruce E, Seebohm Guiscard, Föller Michael, Lang Florian
Abstract excerpt
The inward rectifier K(+) channel Kir2.1 participates in the maintenance of the cell membrane potential in a variety of cells including neurons and cardiac myocytes. Mutations of KCNJ2 encoding Kir2.1 underlie the Andersen-Tawil syndrome, a rare disorder clinically characterized by periodic paralysis, cardiac arrhythmia and skeletal abnormalities. The maintenance of the cardiac cell membrane potential is...
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