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Article

Downregulation of Kv1.5 K channels by the AMP-activated protein kinase.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2012

Mia Sobuj, Munoz Carlos, Pakladok Tatsiana, Siraskar Gulab, Voelkl Jakob, Alesutan Ioana, Lang Florian

Abstract excerpt

BACKGROUND: The voltage gated K(+) channel Kv1.5 participates in the repolarization of a wide variety of cell types. Kv1.5 is downregulated during hypoxia, which is known to stimulate the energy-sensing AMP-activated serine/threonine protein kinase (AMPK). AMPK is a powerful regulator of nutrient transport and metabolism. Moreover, AMPK is known to downregulate several ion channels, an effect at least in part due...

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PMID: 23221389
DOI: 10.1159/000341480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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