Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resequencing of pooled DNA for detecting disease associations with rare variants.

Genetic epidemiology - 1 Jul 2010

Wang Tao, Lin Chang-Yun, Rohan Thomas E, Ye Kenny

Abstract excerpt

A combination of common and rare variants is thought to contribute to genetic susceptibility to complex diseases. Recently, next-generation sequencers have greatly lowered sequencing costs, providing an opportunity to identify rare disease variants in large genetic epidemiology studies. At present, it is still expensive and time consuming to resequence large number of individual genomes. However, given that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Case-Control Studies
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genetics, Population

Share to Models, Genetic

Share to Models, Statistical

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 20578089
DOI: 10.1002/gepi.20502
PMCID: PMC4096227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resequencing of pooled DNA for detecting disease associations with rare variants.PMID 20578089Read ↗

Pooled association tests for rare variants in exon-resequencing studies.Semantic proximity Read ↗

Design of association studies with pooled or un-pooled next-generation sequencing data.Semantic proximity Read ↗

A statistical method for the detection of variants from next-generation resequencing of DNA pools.Semantic proximity Read ↗

A comparison of association statistics between pooled and individual genotypes.Semantic proximity Read ↗

A groupwise association test for rare mutations using a weighted sum statistic.Semantic proximity Read ↗

Biases and errors on allele frequency estimation and disease association tests of next-generation sequencing of pooled samples.Semantic proximity Read ↗

The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA.Semantic proximity Read ↗

Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypes.Semantic proximity Read ↗

Investigation of rare and low-frequency variants using high-throughput sequencing with pooled DNA samples.Semantic proximity Read ↗

SNP frequency estimation using massively parallel sequencing of pooled DNA.Semantic proximity Read ↗

On optimal pooling designs to identify rare variants through massive resequencing.Semantic proximity Read ↗

A unified approach for allele frequency estimation, SNP detection and association studies based on pooled sequencing data using EM algorithms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.