Article
Design of association studies with pooled or un-pooled next-generation sequencing data.
Genetic epidemiology - 1 Jul 2010
Kim Su Yeon, Li Yingrui, Guo Yiran, Li Ruiqiang, Holmkvist Johan, Hansen Torben, Pedersen Oluf, Wang Jun, Nielsen Rasmus
Abstract excerpt
Most common hereditary diseases in humans are complex and multifactorial. Large-scale genome-wide association studies based on SNP genotyping have only identified a small fraction of the heritable variation of these diseases. One explanation may be that many rare variants (a minor allele frequency, MAF <5%), which are not included in the common genotyping platforms, may contribute substantially to the genetic...
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