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Article

Allele frequency distributions in pooled DNA samples: applications to mapping complex disease genes.

Genome research - 1 Feb 1998

Shaw S H, Carrasquillo M M, Kashuk C, Puffenberger E G, Chakravarti A

Abstract excerpt

Genetic studies of complex hereditary disorders require for their mapping the determination of genotypes at several hundred polymorphic loci in several hundred families. Because only a minority of markers are expected to show linkage and association in family data, a simple screen of genetic markers to identify those showing linkage in pooled DNA samples can greatly facilitate gene identification. All studies...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9477339
DOI: 10.1101/gr.8.2.111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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