An evaluation of allele frequency estimation accuracy using pooled sequencing data.

Abstract excerpt

Next generation sequencing technology has matured, and with its current affordability, will replace the SNP chip as the genotyping tool of choice. Even with the current affordability of NGS, large scale studies will require careful study design to reduce cost. In this study, we designed an experiment to assess the accuracy of allele frequency estimated from pooled sequencing data. We compared the allele frequency...

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• Gene Frequency
• Genome-Wide Association Study
• High-Throughput Nucleotide Sequencing
• Oligonucleotide Array Sequence Analysis
• Polymorphism, Single Nucleotide