Article
Identification of nuclear localization and nuclear export signals in Ets2, and the transcriptional regulation of Ets2 and CTP:phosphocholine cytidylyltransferase alpha in tetradecanoyl-13-acetate or macrophage-colony stimulating factor stimulated RAW264 cells.
Biochimica et biophysica acta - 1 Mar 2009
Okamura Koichi, Yamashita Satoko, Ando Hiromi, Horibata Yasuhiro, Aoyama Chieko, Takagishi Kenji, Izumi Takashi, Vance Dennis E, Sugimoto Hiroyuki
Abstract excerpt
PC is made via the CDP-choline pathway, in which CTP:phosphocholine cytidylyltransferase alpha (CTalpha), encoded by Pcyt1a, is the rate-limiting enzyme whose mRNA expression is strictly regulated. Previously, we reported that Ets1 enhanced and Net repressed CTalpha transcription by binding at the Ets binding site (-49/-47) in the Pcyt1a promoter. In this study, we asked if an Ets1 analogue, Ets2, also regulates...
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