Article
A novel cyclic AMP response element, CACTTGATC, mediates forskolin induction of the myelin basic protein promoter in the rat Schwannoma line, D6P2T.
Journal of neurochemistry - 1 Jul 1994
Li X, Wrabetz L, Cheng Y, Kamholz J
Abstract excerpt
The rat Schwannoma cell line D6P2T constitutively expresses the mRNA encoding the major myelin protein, P0, but only expresses the mRNA encoding myelin basic protein (MBP) after exposure to forskolin or other substances that raise the levels of intracellular cyclic AMP. In this study we have investigated the molecular basis for forskolin induction of MBP transcription in D6P2T cells. We have found that a 9-bp...
Topics
- Animals
- Base Sequence
- Chloramphenicol O-Acetyltransferase
- Colforsin
- Cyclic AMP Response Element-Binding Protein
- Deoxyribonuclease I
- Gene Expression Regulation, Neoplastic
- Molecular Sequence Data
- Mutation
- Myelin Basic Protein