Article
Transcriptional and post-translational regulation of mouse cation transport regulator homolog 1.
Molecular and cellular biochemistry - 1 Aug 2013
Oh-Hashi Kentaro, Nomura Yuki, Shimada Kiyo, Koga Hisashi, Hirata Yoko, Kiuchi Kazutoshi
Abstract excerpt
Recently, cation transport regulator homolog 1 (Chac1) has been identified as a novel pro-apoptotic factor in cells under endoplasmic reticulum (ER) stress. Of the three major ER stress sensors, it is suggested that ATF4 participates in the transcriptional regulation of Chac1 gene expression. The precise characterization of the Chac1 promoter, however, has not yet been elucidated. In this study, we detected the...
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