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Article

The rate-limiting enzyme in phosphatidylcholine synthesis regulates proliferation of the nucleoplasmic reticulum.

Molecular biology of the cell - 1 Mar 2005

Lagace Thomas A, Ridgway Neale D

Abstract excerpt

The nucleus contains a network of tubular invaginations of the nuclear envelope (NE), termed the nucleoplasmic reticulum (NR), implicated in transport, gene expression, and calcium homeostasis. Here, we show that proliferation of the NR, measured by the frequency of NE invaginations and tubules, is regulated by CTP:phosphocholine cytidylyltransferase-alpha (CCTalpha), the nuclear and rate-limiting enzyme in the...

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Identifiers

PMID: 15635091
DOI: 10.1091/mbc.e04-10-0874
PMCID: PMC551478

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