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Article

Role of the lysine-rich cluster of the C2 domain in the phosphatidylserine-dependent activation of PKCalpha.

Journal of molecular biology - 23 Jan 2004

Rodríguez-Alfaro Jose A, Gomez-Fernandez Juan C, Corbalan-Garcia Senena

Abstract excerpt

The C2 domain of PKCalpha is a Ca(2+)-dependent membrane-targeting module involved in the plasma membrane localization of the enzyme. Recent findings have shown an additional area located in the beta3-beta4 strands, named the lysine-rich cluster, which has been demonstrated to be involved in the PtdIns(4,5)P(2)-dependent activation of the enzyme. Nevertheless, whether other anionic phospholipids can bind to this...

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Identifiers

PMID: 14698304
DOI: 10.1016/j.jmb.2003.10.080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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