Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter.

The Journal of biological chemistry - 18 Feb 2011

Matsuo Akinori, Bellier Jean-Pierre, Nishimura Masaki, Yasuhara Osamu, Saito Naoaki, Kimura Hiroshi

Abstract excerpt

Choline acetyltransferase (ChAT) synthesizes the neurotransmitter, acetylcholine, at cholinergic nerve terminals. ChAT contains nuclear localization signals and is also localized in the nuclei of neural and non-neuronal cells. Nuclear ChAT might have an as yet unidentified function, such as transcriptional regulation. In this study, we investigated the alteration of candidate gene transcription by ChAT. We chose...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Acetylcholine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Active Transport, Cell Nucleus

Share to Choline O-Acetyltransferase

Share to HEK293 Cells

Share to Neurons

Share to Organ Specificity

Share to Symporters

Source

Open in PubMed Open full text

Identifiers

PMID: 21163949
DOI: 10.1074/jbc.M110.147611
PMCID: PMC3037696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter.PMID 21163949Read ↗

Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia.Semantic proximity Read ↗

Cell Type-specific Regulation of Choline Acetyltransferase Gene ExpressionSemantic proximity Read ↗

A cell type-specific silencer in the human choline acetyltransferase gene requiring two distinct and interactive E boxes.Semantic proximity Read ↗

Detection of choline transporter‐like 1 protein CTL1 in neuroblastoma × glioma cells and in the CNS, and its role in choline uptakeSemantic proximity Read ↗

Structural insights and functional implications of choline acetyltransferase.Semantic proximity Read ↗

The Cholinergic Gene LocusSemantic proximity Read ↗

Cloning and characterization of the choline acetyltransferase structural gene (cha-1) from C. elegans.Semantic proximity Read ↗

Functional identification of a vesicular acetylcholine transporter and its expression from a “cholinergic” gene locus.Semantic proximity Read ↗

Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1Semantic proximity Read ↗

Differentiation of cholinergic neurons and physiological role of ciliary neurotrophic factor (CNTF).Semantic proximity Read ↗

Determination of allelic expression of SNP rs1880676 in choline acetyltransferase gene in HeLa cells.Semantic proximity Read ↗

The Cholinesterases: From Genes to ProteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.