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Article

Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity.

Journal of neurochemistry - 1 Apr 2009

Guo Huang, Wang Yaoming, Singh Itender, Liu Dong, Fernández José A, Griffin John H, Chow Nienwen, Zlokovic Berislav V

Abstract excerpt

Activated protein C (APC) is a protease with anticoagulant and cytoprotective activities. APC is neuroprotective in rodent models of stroke. But, an APC variant with reduced anticoagulant activity, 3K3A-APC, compared to wild-type APC shows greater neuroprotection with no risk for bleeding in stroke models. To determine whether 3K3A-APC exhibits species-dependent neuroprotection similar to that as seen with...

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Source

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Identifiers

PMID: 19166505
DOI: 10.1111/j.1471-4159.2009.05921.x
PMCID: PMC2692505

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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