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Article

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Apr 2013

Guo Huang, Zhao Zhen, Yang Qi, Wang Min, Bell Robert D, Wang Su, Chow Nienwen, Davis Thomas P, Griffin John H, Goldman Steven A, Zlokovic Berislav V

Abstract excerpt

Activated protein C (APC) is a protease with anticoagulant and cell-signaling activities. In the CNS, APC and its analogs with reduced anticoagulant activity but preserved cell signaling activities, such as 3K3A-APC, exert neuroprotective, vasculoprotective, and anti-inflammatory effects. Murine...

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Identifiers

PMID: 23554499
DOI: 10.1523/JNEUROSCI.4491-12.2013
PMCID: PMC3707621

Genes

APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23554499-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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