Article
Protein C anticoagulant and cytoprotective pathways.
International journal of hematology - 1 Apr 2012
Griffin John H, Zlokovic Berislav V, Mosnier Laurent O
Abstract excerpt
Plasma protein C is a serine protease zymogen that is transformed into the active, trypsin-like protease, activated protein C (APC), which can exert multiple activities. For its anticoagulant action, APC causes inactivation of the procoagulant cofactors, factors Va and VIIIa, by limited proteolysis, and APC's anticoagulant activity is promoted by protein S, various lipids, high-density lipoprotein, and factor V....
Topics
- Animals
- Anticoagulants
- Cytoprotection
- Enzyme Activation
- Humans
- Models, Molecular
- Mutation
- Protein C
- Protein S
- Receptors, Cell Surface
- Signal Transduction
- Thrombomodulin
- Venous Thrombosis