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Article

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity.

The European journal of neuroscience - 1 Mar 2009

Guo Huang, Singh Itender, Wang Yaoming, Deane Rashid, Barrett Theresa, Fernández José A, Chow Nienwen, Griffin John H, Zlokovic Berislav V

Abstract excerpt

The anticoagulant activated protein C (APC) protects neurons and endothelium via protease activated receptor (PAR)1, PAR3 and endothelial protein C receptor. APC is neuroprotective in stroke models. Bleeding complications may limit the pharmacologic utility of APC. Here, we compared the 3K3A-APC mutant with 80% reduced anticoagulant activity and wild-type (wt)-APC. Murine 3K3A-APC compared with wt-APC protected...

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Identifiers

PMID: 19302148
DOI: 10.1111/j.1460-9568.2009.06664.x
PMCID: PMC2692517

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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