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Article

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.

Blood - 4 Jun 2009

Mosnier Laurent O, Zampolli Antonella, Kerschen Edward J, Schuepbach Reto A, Banerjee Yajnavalka, Fernández José A, Yang Xia V, Riewald Matthias, Weiler Hartmut, Ruggeri Zaverio M, Griffin John H

Abstract excerpt

Activated protein C (APC) reduces mortality in severe sepsis patients. APC exerts anticoagulant activities via inactivation of factors Va and VIIIa and cytoprotective activities via endothelial protein C receptor and protease-activated receptor-1. APC mutants with selectively altered and opposite activity profiles, that is, greatly reduced anticoagulant activity or greatly reduced cytoprotective activities, are...

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Share to Cytoprotection
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19244160
DOI: 10.1182/blood-2008-10-183327
PMCID: PMC2700330

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.PMID 19244160Read ↗

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