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Article

Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice.

Blood cells, molecules & diseases - 1 Aug 2013

Wang Yaoming, Sinha Ranjeet Kumar, Mosnier Laurent O, Griffin John H, Zlokovic Berislav V

Abstract excerpt

Wild type (WT) activated protein C (APC) and cytoprotective-selective APC variants such as 3K3A-APC (<10% anticoagulant but normal cytoprotective activity) are neuroprotective in murine focal ischemic stroke models. Here we compared the neuroprotective effects of the anticoagulant-selective E149A-APC variant (>3-fold increased anticoagulant activity but defective cytoprotective activities) to those of the...

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Source

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Identifiers

PMID: 23541526
DOI: 10.1016/j.bcmd.2013.02.009
PMCID: PMC3812054

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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