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Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

21 Jun 2013

Abstract excerpt

The direct cytoprotective activities of activated protein C (APC) on cells convey therapeutic, relevant, beneficial effects in injury and disease models in vivo and require the endothelial protein C receptor (EPCR) and protease activated receptor 1 (PAR1). Thrombin also activates PAR1, but its effects on cells contrast APC's cytoprotective effects. To gain insights into mechanisms for these contrasting cellular...

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PMID: 23788139
DOI: 10.1182/blood-2013-03-488957

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