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Article

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity.

Blood - 15 Sept 2004

Mosnier Laurent O, Gale Andrew J, Yegneswaran Subramanian, Griffin John H

Abstract excerpt

Recombinant activated protein C (APC), a well-defined anticoagulant enzyme, reduced mortality in severe sepsis patients in a phase 3 trial. However, 2 potent anticoagulants, antithrombin III and recombinant tissue factor pathway inhibitor, failed to do so, implying the physiologic relevance of APC's less well-defined anti-inflammatory and antiapoptotic activities. Recombinant APC therapy conveys an increased risk...

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Share to Anticoagulants
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoprotection

Share to Endothelial Cells

Share to Endothelins

Share to Protein C

Share to Receptor, PAR-1

Source

Identifiers

PMID: 15178575
DOI: 10.1182/blood-2004-01-0110

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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